In a vain attempt to stop multiple governmental genocides due to overpopulation, Charlie, the princess of Hell, opens up the Happy Hotel to "rehabilitate sinners" with her partner and girlfriend, the short-tempered Vaggie. They first attempt to rehabilitate Angel Dust, a sassy gay porn star. His "progress" and his actions put the hotel on dangerous ground. More trouble seems to arise when the mysterious Radio Demon takes interest, deeming Charlie's dream "Hazbin Hotel".