Chicago, 1993. At his 23 years-old, James Fray is a lost soul stuck in a spiral of auto-destruction due to his addiction to drugs and alcohol. After a night of partying, James accidentally falls off the balcony of the house where he was staying, breaking his nose. When he comes to from his alcohol and drug-fueled high hours later, he finds himself on an airplane headed to Minnesota, to be admitted in Hazelden Foundation, a legendary rehab center for addicts. Reluctant to take any step to address his addictions, in the center he meets other patients in treatment: Leonard, a foul-mouthed former member of the mob; John, a deranged sexual obsessive unable to contain his primary impulses; Roy, a bipolar disorder combined with religious delirium; and finally Miles, a clarinet player and former judge who turns on his roommate. Despite the rules of the center that prevent all contact between men and women, who are treated in different pavilions of the center, James meets Lilly, a beautiful and fragile young girl with ...